흰쥐에서 신델라 겔 (송아지 제단백혈액추출물 : 황산미크로노마이신=20:1 복합제제)의 30일간 반복투여 경피독성시험

• 영문명: Subacute Transdermal Toxicity Study of Syndella gel, Topical Drug Containing Deproteinised Dialysate of Calf''s Blood and Micronomicin sulfate, in Rats
• 발행기관: 대한약학회
• 저자명: 남석우(Suk Woo Nam) 성대석(Dae Suk Sung) 유세근(Se Keun Yoo) 장만식(Man Sik Chang) 최완수(Wahn Soo Choi) 정영국(Young Kuk Chung) 김규봉(Kyu Bong Kim) 한정환(Jeung Whan Han) 홍성렬(Sung Youl Hong) 이향우(Hyang Woo Lee)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 203~211쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

This study was conducted to investigate the subacute transdermal toxicity of Syndella gel, a new topical drug containing deproteinized dialysate of calf''s blood and micronomicin sulfate in Sprague-Dawley rats. Three doses (1.97, 3.94, 7.88 g/kg) of Syndella gel was daily treated transdermally to male and female rats for 30 days. No death was occurred in either control or treated rats. No significant toxic clinical signs and body weight change were not observed at any doses in the male or female rats treated. There were no significant alterations in hematologic and biochemical parameters in both sexes, however slight increase of potassium concentration was observed in 3.94g/kg and 7.88 g/kg female groups. No significant necrotic changes were not observed in examined organs. This study showed that up to 7.88g/kg Syndella gel did not induce subacute transdermal toxicity.

키워드

Syndella gel Subacute transdermal toxicity.