메틸유제놀에 의한 즉시형 과민 반응의 억제

• 영문명: Suppression of Immediate Hypersensitivity by Methyleugenol
• 발행기관: 대한약학회
• 저자명: 김창영(Chang Young Kim) 신태용(Tae Yong Shin) 김형민(Hyung Min Kim)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 268~272쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

We studied the action of methyleugenol on immediate hypersensitivity. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol also inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. These results suggest that the inhibitory effect of methyleugenol on anaphylaxis induced by compound 48/80 or anti-DNP IgE is due to, in part at least, the membrane stabilization of mast cells.

키워드

Methyleugenol Anaphylaxis Compound 48/80 Anti-dinitrophenyl (DNP) IgE Histamine Mast cells.