천연물로부터 프롤릴 엔도펩티다제 저해제의 검색

• 영문명: Screening of Prolyl Endopeptidase Inhibitors from Natural Products
• 발행기관: 대한약학회
• 저자명: 이경희(Kyung Hee Lee) 이현진(Hyun Jin Lee) 박훈일(Hun Il Park) 홍은옥(Eun Ok Hong) 송경식(Kyung Sik Song)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 153~160쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

One hundred and seventy crude drugs were screened for prolyl endopeptidase (PEP) inhibitors. Among them, 80% methanolic extract of 18 medicinal plants such as Polygonum cuspidata, Sanguisorba officinalis, Eugenia caryophyllata, Rubus coreanus, Cinnamomum cassia (Cassiae Cortex and Cinammomi Ramulus), Rheum palmatum, Ulmus pumila, Sorbus commixta, Areca catechu, Uncaria sinensis, Terminalia chebula, Caesalpinia sappan, Nelumbo nucifera, Machilus thunbergii, Paeonia moutan, Elscholtzia patrini and Cynomorium coccineum inhibited more than 70% of PEP activity at a concentration of 40 ppm. The active principles of P. moutan, M. thunbergii, T chebula, A. catechu, S. commixta, R. palmatum, R. coreanus, E. caryophyllata and P. cuspidata were transferred into organic solvents, which showed more than 75% inhibition at 5 ppm.

키워드

Alzheimer disease Prolyl endopeptidase inhibitor Screening Natural products.