흰쥐에서 위장관에 작용하는 생약의 진경 및 항위궤양 효능

• 영문명: Spasmolytic and Anti-peptic Ulcer Activities of Crude Drugs Acting on Gastrointestinal Tract in Rats
• 발행기관: 대한약학회
• 저자명: 조승길(Seung Kil Cho) 박혜란(Hye Ran Park) 김창종(Chang Jong Kim)
• 간행물 정보: 『약학회지』제40권 제5호 (1996년), 591~598쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.10.31

영문 초록

The water extracts of ten crude drugs were tested for the spasmolytic and anti-peptic ulcer activities on rat ileum smooth muscle contraction and aspirin-induced acute hemorrhagic erosive gastritis respectively. The water extract of Aurantii immaturi pericarpium(AIP)(IC50=1.5 X 1O-2g/l), Aurantii nobilis pericarpium(ANP)(IC50=2.5 X 1O-2g/l), Cyperi rhizoma(CR)(IC50=3.3 X 1O-2g/l). Linderae radix(LR) (IC50=6.8 X 1O-2g/l), Aurantii fructus immaturus(AFI)(IC50=23.3 X 1O-2g/l), Saussureae radix(SR)(IC50=13.2 X 1O-2g/l) and Ponciri fructus(PF)(IC50=23.3 X 1O-2g/l) showed inhibitory activity on the isometric contraction of rat ileum smooth muscle induced by electrical stimulation in a concentration-dependent manner, whereas the water extracts of Arecae pericarpium(AP), Agastachis herba(AH) and Magnoliae cortex(MC) potentiated the isometric contraction. In the aspirin-induced acute gastritis, the water extracts of MC, AP and CR reduced significantly the gastric juice secretion, gastric juice acidity and pepsin activity. They also showed protective activity of gastric mucosal layer from erosion and petichial hemorrhage in gross and histological examination.

키워드

Aurantii nobilis pericarpium Aurantii immaturi pericarpium Aurantii fructus immaturus Ponciri fructus Magnoliae cortex Saussureae radix Agastachis herba Linderae radix Arecae pericarpium Cyperi rhizoma Spasmolytic activity Anti-peptic ulcer activity.