(-)-4-(파라클로로비페닐)-2-히드록시테트론 산의 합성

• 영문명: Synthesis of (-)-4-(p-Chlorobiphenyl)-2-hydroxytetronic Acid
• 발행기관: 대한약학회
• 저자명: 권순경(Soon Kyoung Kwon) Donald T. Witiak
• 간행물 정보: 『약학회지』제40권 제5호 (1996년), 539~544쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.10.31

영문 초록

4-Aryl-2-hydroxytetronic acids which can be construded as a "lipophilic vitamin C analogue", are known to have antilipidemic and antiaggregatory activities in stead of antiscorbutic activity of vitamin C. A new compound 4-(p-chlorobiphenyl)-2-hydroxytetronic acid (8), which is structurally closely connected with the most active 4-(p-chlorophenyl)-2-hydroxytetronic acid, was synthesized from alpha-(p-chlorobiphenyl)-alpha-hydroxyacetic acid (1) through 7 steps as a potentially bioactive compound.

키워드

(-)-Methyl a-(p-chlorobiphenyl)-a-hydroxyacetate 2-hydroxytetronic acid (-)-4-(pchlorobiphenyl)-2-hydroxytetronic acid antilipidemic activity antiaggregatory activity