새로운 알릴아민 항진균제의 합성과 생물학적 평가

• 영문명: Synthesis and Biological Evaluation of New Allylamine Antimycotics
• 발행기관: 대한약학회
• 저자명: 정병호(Byung Ho Chung) 박은주(Eun Ju Park) 문현주(Hyun Ju Moon) 유진철(Jin Cheol Yoo)
• 간행물 정보: 『약학회지』제40권 제5호 (1996년), 507~512쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.10.31

영문 초록

Some allylamine compounds which are benzothiazole substituants in stead of naphthyl ring in naftifine, antifungal agents, were synthesized as potential antimycotics. The intermediate Schiff bases that were obtained by condensation of 2-aminobenzothiazole and trans-cinnamaldehyde, were reduced to imine compounds to give allylamines (5a-5d) after methylation. These compounds which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes, showed no activity in 0.1~100mcg/ml range.

키워드

trans-Cinnamaldehyde 2-amino-6-chlorobenzothiazole 2-amincr6-bromobenzothiazole 2-amino-6-ethoxybenzothiazole 2-(4-aminophenyl)-6-methylbenzothiazole 4-chloroaniline 4-bromoaniline.