흰쥐에 있어서 톨루엔 흡입노출이 시간경과에 따른 혈중 톨루엔농도 및 행동변화에 미치는 영향

• 영문명: The Effects of Toluene Inhalation on Blood Toluene Concentration in Time Sequence and Behavioral Change in Rats
• 발행기관: 대한약학회
• 저자명: 백승경(Seung Kyung Baeck) 노일협(Ihl Hyeob Ro)
• 간행물 정보: 『약학회지』제40권 제5호 (1996년), 545~549쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.10.31

영문 초록

Male Sprague-Dawley rats were exposed to the toluene at 3,000 +/- 200ppm via inhalation for two hours in the single inhalation group and three weeks by two hours per day, six days per week in the repeated inhalation group. The blood toluene concentration in the repeated inhalation group was significantly lower than that in the single inhalation group after 210 and 240 minutes of exposure. The peak concentration of blood toluene was 58.13 +/- 4.63mcg/ml in the single inhalation group and 54.24 +/- 6.87mcg/ml in the repeated at the end of 120 minutes of the exposure. The behavioral change of rats for the initial 30 minutes of the toluene inhalation showed mildly increased movement and excitement but remained calm and inhibitory behaviors after that period; more inhibitory behaviors in the single inhalation group compared with the repeated inhalation group. In open-field test, after the termination of the toluene inhalation, no difference had been statistically observed between the toluene inhalation group and the control group in ambulation, rearing, preening and grooming.

키워드

Toluene inhalation behavior rat.