피록시캄 결정형의 용출과 형전환

• 영문명: Dissolution and Transformation of Crystal Forms of Piroxicam
• 발행기관: 대한약학회
• 저자명: 손영택(Young Taek Sohn)
• 간행물 정보: 『약학회지』제40권 제5호 (1996년), 513~521쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.10.31

영문 초록

The polymorphism of piroxicam was studied. Form I, II, III and monohydrate designated as Form IX were prepared by recrystallization from different solvents. Depending on the cooling rate of the piroxicam melt, Form IV, V, VI, VII and VIII were prepared. The crystal forms were characterized by DTA, TGA and UV spectroscopy. Their dissolution patterns were also investigated. During storage at ambient condition. Form VIII was transformed into Form I and it was accelerated by milling. The other crystal forms were also transformed into Form I by milling. Form I and Form IX were very stable.

키워드

Polymorphism Monohydrate Piroxicam Recrystallization Melt Dissolution Transformation Milling Compression DTA TGA.