흰쥐에 재조합 인간 상피세포 성장인자(DWP401)를 연용피하투여했을 때 약물체내동태

• 영문명: Pharmacokinetics of Recombinant Human Epidermal Growth Factor (DWP401) after Repeated Subcutaneous Administration to Rats
• 발행기관: 대한약학회
• 저자명: 남권호(Kweon Ho Nam) 조재열(Jae Youl Cho) 정주영(Joo Young Chung) 장우익(Woo Ik Chang) 강진석(Jin Seok Kang) 유은숙(Eun Sook Yoo) 박승국(Seung Kook Park) 유영효(Young Hyo Yu) 박명환(Myung Hwan Park) 심창구(Chang Koo Shim)
• 간행물 정보: 『약학회지』제40권 제5호 (1996년), 491~500쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.10.31

영문 초록

The organ distribution and pharmacokinetics of DWP401, a recombinant human epidermal growth factor (rhEGF), were compared after single and repeated subcutaneous administration (50mcg/kg, 10mcCi/kg of 125I-DWP401, twice a day for 7 consecutive days) to rats. The pharmacokinetic parameters such as AUC and terminal half-life were similar between two different administration. During repeated administration, the plasma concentration of DWP401 seemed to be constant when the plasma was collected at 15 min after each dosing. The TCA-precipitated radioactivities in thyroid, liver, kidney, and stomach were higher than those of other organs studied after both single and repeated administration. The TCA-precipitated radioactivities after repeated administration in several organs, such as thyroid, stomach, prostate, adrenal, eye ball, and testis were higher than those after single administration. But, according to the observations using gel filtration chromatography and antibody binding assay, the radioactivities in thyroid and stomach were not primarily due to the intact DWP401 or its metabolites but due to the 125I-thyroxine binding protein. In conclusion, it can be suggested that DWP401 is metabolized to each amino acid or small polypeptides, and there was no significant changes in pharmacokinetics or any indications for accumulation of DWP401 in rat plasma and organs after repeated treatment.

키워드

Pharmacokinetics DWP401 rhEGF multiple dose organ distribution accumulation.