IL-1/Toll-like Receptor Superfamily 신호전달에 관여하는 TRAF6 결합 Motif의 규명

• 영문명: Identification of TRAF6-Binding Motif in IL-1/Toll-like Receptor Superfamily-Mediated Signal Transduction
• 발행기관: 대한약학회
• 저자명: 임미정(Mi Jung Yim)
• 간행물 정보: 『약학회지』제47권 제3호 (2003년), 180~183쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.06.30

영문 초록

Crystal structure of TRAF6 in complex with TRAF6-binding sites from CD4O was previously determined. The structure revealed a distinct TRAF6-binding groove of CD4O, the key structural determinant of interaction. The structural information leads to a proposed TRAF6-binding motif. This allows the identification of TRAF6-binding sequences in the hIRAK protein, whose functional requirement in IL-1/Toll-like eceptor superfamilies-mediated signal transduction is further demonstrated using site- directed mutagenesis. The mutational effects of MRAK on the down-stream NF-KB signaling shows the importance of the TRAF6 interface for signaling by IL-1/Toll-like receptor superfamilies.

키워드

TRAF6-binding motif hIRAK IL-l/To1l-like receptor superfamilies NF-kB.