가스크로마토그래피 - 질량분석기를 이용한 모발에서 암페타민형 각성제 약물의 동시 분석

• 영문명: Simultaneous Determination of Amphetamine-Type Stimulants (ATS) in Human Hair by GC-MS
• 발행기관: 대한약학회
• 저자명: 김진영(Jin Young Kim) 서승일(Sung Ill Suh) 고범준(Beom Jun Ko) 이재일(Jae Il Lee) 정재철(Jae Chul Jeong) 서용준(Yong Jun Suh) 인문교(Moon Kyo In)
• 간행물 정보: 『약학회지』제47권 제3호 (2003년), 142~147쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.06.30

영문 초록

Gas chromatography-mass spectrometric (GC-MS) procedure is presented for the simultaneous qualification and quantitation of methamphetamine (MA), amphetamine (AMP), 3,4-methylenedioxymethamphetamine (MDEA), 3,4-methylenedioxyamphetamine (MDA), and 3,4-methylenedioxyethylamphetamine (MDEA) in human hair, The method procedure involves decontamination of hair with distilled water and acetone, acidic hydrolysis, extraction in the presence of deuterated internal standards, and GC-MS analysis after derivati3ation with trifluoroacetic anhydride (TFAA) in ethylacetate, The limit of detection for 5 drugs were about 0.1~0.15 ng/mg using 30 mg hair sample. Coefficient variations of correlation ranged from 0.9941 to 0.9993. The recoveries of these drugs were found to be 93.4~104.4%. The concentrations of AMP, MA, MDA, and MDMA in abusers' hair samples were measured 0.17~2.88, 2.09~18,34, 0.24~3.83, and 3.10~22.81 ng/mg, respectively. The ratios of MA/AMP and MDMA/MDA ranged 5.67~49.57 and 4.78~54.31, respectively, This assay has been successfully utilized in the evaluation of the deposition of amphetamine-type stimulants (ATS) in human hair.

키워드

ATS methamphetamine amphetamine MDMA MDA MDEA hair GC-MS.