2 위치가 치환된 5-니트로 Benzimidazole 유도체들의 Topoisomerase I 억제 활성

• 영문명: Topoisomerase I Inhibition of 2-Substituted 5-Nitrobenzimidazoles
• 발행기관: 대한약학회
• 저자명: 권민진(Min Jin Kwon) Edmond J. Lavoie 김정선(Jung Sun Kim)
• 간행물 정보: 『약학회지』제47권 제3호 (2003년), 125~129쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.06.30

영문 초록

A stories of 2-phenyl-5-nitrobenzimidazoles substituted at the para positron of the 2- phenyl moiety was sinthesized & evaluated for their activity to inhibit topoisomerase I. The structure-activity relationship study revealed that neither the electronic nor lipophilic parameters were related to the topoisomerase I inhibition. A strict spatial requirement seems to be present for retention of topoisomerase I inhibition activity.

키워드

2-Phenyl-5-nitrobenzimidazole topoisomerase I inhibition structure-activity relationship.