반려동물의 장내 마이크로바이옴과 약물의 상호 작용; 중개연구 관점

• 영문명: Interaction between Gut Microbiome and Drugs in Companion Animals; translational aspects
• 발행기관: 한국동물보건학회
• 저자명: 윤소라(Sorah Yoon)
• 간행물 정보: 『한국동물보건학회지』3권 1호, 1~11쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.03.30

영문 초록

Drug responses are showed in individual variability. It can be main causes of adverse drug reactions or extended therapies, which result in burden of substantial health. Despite of extensive investigation in pharmacogenomics in terms of the impact of individual genetics on drug-metabolism, a limited proportion of drug-individual variability explains genetic diversity. The gut microbiota and its metabolites have been proven a role to modulate therapeutic outcomes in diseases. Therefore, in this article, we present the interaction between microbiota and drug responses in companion animal diseases, including cancer, endocrine diseases, and others. Also, we summarize how microbiota modify metabolism and distribution of drugs. The practical challenges and opportunities are also discussed in this new field, emphasizing the needs to translate human data into clinical veterinary practice. In summary pharmacomicrobiomics, the interaction between gut microbiota and drug response, may be a promising research field to improve the outcomes of drug effects in patients.

목차

1. Introduction

2. Microbiome in cancer immunotherapy

3. Microbiome in chemotherapy

4. Microbiome-gut-brain axis

5. Gut microbiome linked with metabolic and immune diseases

6. Conclusion

Conflict of interest statement

ORCID

REFERENCES

키워드

Companion animals Drug Gut-microbiota Metabolism Pharmacomicrobiomics