Quercetin이 B16/F10멜라닌세포의 증식 및 멜라닌화에 미치는 영향

• 영문명: In vitro Modulation of Proliferation and Melanization of B16/F10 Melanoma Cells by Quercetin
• 발행기관: 대한약학회
• 저자명: 천현자(Hyun Ja Chun) 황상구(Sang Gu Hwang) 김춘관(Chun Kwan Kim) 전병훈(Byung Hun Jeon) 백승화(Seung Hwa Baek) 우원홍(Won Hong Woo)
• 간행물 정보: 『약학회지』제46권 제1호 (2002년), 75~80쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

Quercetin is one of the bioflavonoid compounds and has multiple biological effects such as antioxidant and effective anti-inflammatory agent. Melanin has an important role in protecting human skin from the damaging effects of ultra-violet (UV) radiation. We studied the effect of quercetin on proliferation of B16/F10 melanoma cells. After 48h treatment of cells with quercetin, the cells exhibited a dose- dependent inhibition in their proliferation without apoptosis. Therefore, the decrease in cell numbers may be due to cell growth arrest, not due to cell death by cytotoxiciy. We also investigated the effect of quercetin on melanogenesis of this cells. B16/F10 melanoma cells were grown for 48h in the presence of 0.01∼50μg/ml Quercetin and the total melanin contents were measured. Quercetin stimulated melanization of the cells in low concentrations (0.01-20μg/ml), whereas it inhibited melanization in high concentrations (30-50 μg/ml). It was observed that quercetin differently regulates melanogenesis of B16/F10 melanoma cells dependent on its concentrations.

키워드

Quercetin B16/F10 melanoma cells melanogenesis tyrosinase activity melanin content.