토끼에서 체내담즙이 아세부톨를의 생체이용률 및 체내동태에 미치는 영향

• 영문명: Ehect of Bile juice on the Bioavailability and Pharmacokinetics of Acebutolol in Rabbits
• 발행기관: 대한약학회
• 저자명: 최준식(Jun Shik Choi)
• 간행물 정보: 『약학회지』제46권 제1호 (2002년), 47~51쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

Although acebutolol (ABT) is almost completely absorbed in the gastrointestinal (GI) tract, oral bioavailability of the drug is low due to extensive first-pass metabolism in the Gl tract and liver, In the present study; bioavailability and pharmacokinetics of ABT was studied in bile duct-bypassed rabbits after oral administration. For ABT the time to reach the plasma peak (Tmax) and mean resident time (MRT) were increased by the treatment. For diacetolol (DAT), a metabolite of ABT area under the plasma concentration-time curve (AUC), T max and plasma half-life were increased by the treatment. These results indicate that oral bioavailability of ABT is associated with the enterohepatic recycling of bile juice components.

키워드

Acebutolol diacetolol bioavailability bypass of bile duct.