노인환자에서 Digoxin의 약동학적 매개변수 변화

• 영문명: A Variation of Pharamcokinetic Parameters of Digoxin in Elderly Patients
• 발행기관: 대한약학회
• 저자명: 박창선(Chang Sun Park) 배성미(Seong Mee Bae) 양성희(Seong Hee Yang) 황보신이(Shinn Hwangbo) 홍경자(Kyung Ja Hong) 장춘곤(Choon Gon Jang) 이석용(Seok Yong Lee)
• 간행물 정보: 『약학회지』제46권 제1호 (2002년), 30~38쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

The elderly patients are the most frequent users of digoxin because of increased prevalence of the two primary indications for digoxin therapy; atrial fibrillation (AF) and congestive heart failure (CHF). This study was Performed to observe a variation in digoxin pharmacokinetic parameters in advancing age and changing kidney function, and to compare the measured clearance with the calculated clearance. The 123 drug monitoring records of inpatients who had achieved steady state concentration of digoxin at a tertiary hospital from April 1999 to October 2001 were reviewed. In advancing age, measured digoxin clearance, volume of distribution and creatinine clearance were reduced. Compared with the calculated digoxin clearance, the measured digoxin clearance was more reduced in patients without CHF Especial1y: in elderly patents without CHF the measured digoxin clearance was lower than the calculated digoxin clearance. In contrast to non-CHF patients the measured value was greater than the calculated value in all CHF patients. Findings from this study indicate that the calculated digoxin clearance in elderly patients without CHF substantially overestimated the true clearance. Thus, it appears that the use of calculated digoxin clearance to estimate serum digoxin concentration may result in underestimation of the true serum concentration in a number of elderly patients without CHF.

키워드

Digoxin Pharmacokinetic Elderly.