HCI에 의한 식도염에서 식도와 하부활약근의 점막과 근육세포의 염증변화

• 영문명: Inf1amma1ory Changes in Esophagus and Lower Esophageal of HCI-elicited Esophagitis in Cats
• 발행기관: 대한약학회
• 저자명: 이승준(Seung Jung Lee) 김창종(Chang Jong Kim) 손의동(Uy Dong Sohn) 이무열(Moo Yeol Lee) 신용규(Yong Kyoo Shin) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제46권 제1호 (2002년), 58~62쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

The underlying mechanism by which the reflux of gastric juice elicits oesophagitis remains unclear. To inverttigate iidlammatory response to HCI in tissue of esophagus and lower esophageal sphincter, experimental esophagitis was elicited by perfusion of 0.1 N HCI in cats. There was no difference in phospholipase A2 (PLA2) activity of tissue between control and esophagitis. Myeloperoxidase activity in esophagitis was significantly greater than that of control. However, his- tamine content in esophageal mucosa of esophagitis was significantly smaller than that of control. These findings suggest that inflammatory response to HCI in esophagitis is related to changes of myeloperoxidase activity and histamine rather than change of PLA2 activity.

키워드

Esophagitis phospholipase A2 myeloperoxidase histamine.