영지버섯 균사체 ( Ganoderma lucidum IYO09)로부터 추출한 단백다당체의 전이암 억제 효과

• 영문명: Antimetastatic Effect of Proteoglycan Isolated from the Mycelium of Ganoderma lucidumIYO09 in vitro and in vivo
• 발행기관: 대한약학회
• 저자명: 백성진(Seong Jin Baek) 김용석(Yong Seok Kim) 용환미(Hwan Mee Yong) 채주병(Ju Byung Chae) 이선애(Sun Ae Lee) 배우철(Woo Chul Bae) 박동우(Dong Woo Park) 김동연(Dong Yeon Kim) 이준우(June Woo Lee) 박승국(Seung Kook Park)
• 간행물 정보: 『약학회지』제46권 제1호 (2002년), 11~17쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.02.28

영문 초록

β-Immunan, a proteoglycan, was isolated from the mycelium of Ganoderma lucidum which belongs to a medicinal mushroom. The effects of β-Immunan on cell- cell and cell-matrix interactions mediated by carbohydrate-recognition and the mechanism responsible for the inhibition of experimental metastasis of Bl6-FIO and B16/BL6 murine melanoma were studied. The results showed that Ganoderma lucidum-Immunan inhibited Bl6-Fl melanoma cell's adhesion to laminin and asialofetuin-induced homotypic aggregation and reduced invasion against Bl6-FIO murine melanoma cells through matrigel in vitro assay: When β-Immunan was intraperitoneally administrated to C57BL/6 mice bearing B16/BL6 murine melanoma cells, it was decreased the number of pulmonary metastatic colony by the dose dependent manner ranging from 20 to 100 mg/kg/day, The results indirectly indicate that clinical treatment with β-Immunan might be expected to exhibit anti-metastatic effect. In the put-monary metastasis, the number of pulmonary metastatic colony of melanoma when β-Immunan was intraperitoneally aduunistrated to C57BL/6 mice bearing Bla/BL6 murine melanoma cells by intravenous injection were decreased by the dose dependent manner ranging from 20 to 100 mg/kg/day.

키워드

Ganoderma lucidum IY009 melanoma cell materigel assay proteoglycan β-Immunan antimetastatic effect.