흰쥐의 복강비만세포에서 ATP와 Compound 48/87에 의한 Histamine유리에 미치는 Econazole의 영향

• 영문명: Effect of Econazole on ATP- and Compound 48/80-Induced Histamine Release in Rat Peritoneal Mast Cells
• 발행기관: 대한약학회
• 저자명: 장용운(Yong Un Jang) 이윤혜(Yun Hye Lee) 이승준(Seung June Lee) 서무현(Moo Hyun Seo) 윤정이(Jeong Yi Yoon) 김창종(Chang Jong Kim) 심상수(Sang Soo Sim)
• 간행물 정보: 『약학회지』제45권 제3호 (2001년), 276~281쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.06.30

영문 초록

3 investigate the different mechanism between ATP and compound 48/80 (C48/80)-induced histamine release, we observed effects of calcium antagonists in histamine release of rat peritoneal mast cells.Verapamil and diltiazgem (voltage-dependent calcium channel blocker) and TMB-8 (a blocker of intracellular calcium release) significantly inhibited ATP-induced histamine release, but did not inhibit C48/80 induced histamine release. Econazole (a blocker of receptor-operated calcium channel) dose-dependently inhibited both and C48/80-inducted histamine release,but inhibitory effect of econarole in ATP-induced histamine release was more potent than that in C48/80-induced histamine. EGTA dote-dependently inhibited ATP and C48/80-induced histamine release, and C48/80-induced histamine release was slightly inhibited by high concentrations (>2 mM) of EGTA. These results suggest that ATP·induced histamine release is related to both intraoellular calcium release and extracellular calcium influx via voltage-dependent calcium channel and receptor-operated calcium channel. C48/80-induced histamine release is related to extracellular calcium influx, specially recetor-operated calcium channel rather tllan voltage-dependent calcium channel.

키워드

Mast cells histamine econazole.