마늘-죽염 제제가 위장 장애 유발 흰쥐의 항산화 효소활성에 미치는 영향

• 영문명: Protective Effect of an Aged Garlic-bamboo Salt Mixture on the Rat with the Alcohol-salicylate Induced Gastropathy
• 발행기관: 대한약학회
• 저자명: 허근(Keun Huh) 김영희(Young Hee Kim) 김대경(Da Qing Jin)
• 간행물 정보: 『약학회지』제45권 제3호 (2001년), 258~268쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.06.30

영문 초록

Gallic has been known to be effective against the gastrointestinal diseases which can be induced by production of oxygen-derived free radical. It has been shown that bamboo salt is effective on the treatment and prevention of various gastrointestinal disorders. Bamboo salt is a processed salt invented by a Korean,ll-Hoon Kim. It has been reported that garlic and bamboo-salt are useful to the treatment of gastric disorders in Korea. To clarify the protective mechanism of the garlic-bamboo salt mixture, the gastropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. In this study we found that the garlic-bamboo salt mixture reduced the severity of hemouhagic lesion in gastric mucosa in the rats. In addition, the activities of superoxide dismutase (SOD), glutathione pemxidase (GPx), glutathione reductase (GR) were signiscnatly increased and the total content of GSH was recovered. From these results, we concluded that the protective effect of the garlic-bamboo salt mixture on gastropathy in rats is its ability to recover the level of GSH and to increase the activities of the free radical scavenging enzymes (SOD, GPx, GR).

키워드

Aged garlic-bamboo salt alcohol-salicylate superoxide dismutase glutathione peroxidase glutathione reductase glutathione.