당뇨병성 심혈관합병증에 대한 KST221085의 개선효과

• 영문명: Improvement of Cardiovascular Dysfunction in Diabetic Rat by KST221085
• 발행기관: 대한약학회
• 저자명: 정이숙(Yi Sook Jung) 한호규(Hoh Gyu Hahn) 이수환(Soo Hwan Lee) 백은주(Eun Joo Baik) 문창현(Chang Hyun Moon)
• 간행물 정보: 『약학회지』제45권 제3호 (2001년), 276~281쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.06.30

영문 초록

The present study was conducted to evaluate the effect of KST221085, a newly synthesized antidiabetic agent, on the hearts from streptozotocin (572)-induced diabetic rats. In isolated diabetic hearts, left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow rate (CFR) were decreased compared to normal control, indicating cardiovascular dysfunction in diabetic heart. The treatment with 10mcM KST221085 remarkably improved the diabetes-induced contractile impairment, without any influence on HR. Reduced coronary flow in diabetic heart was also significantly increased by treatment with 10mcM KST221085, In isolated aorta·on diabetic rat, treatment with 10mcM KST22108S increased endothelium-dependent relaxation, suggesting that KST221085 can improve the impaired endothelial function in diabetic aorta. Our results suggest that KST221085 treatment can improve the cardiovascular dysfunction in STZ-induced diabetic rats.

키워드

Cardiovascular dysfunction diabetes