한국산 겨우살이 (Viscum album coloratum)로부터 정제된 렉틴 성분 KML-IIU의 예비 독성 및 일반 약리 시험

• 영문명: Preliminary Tlxicity and General Pharmacology of KML-IIU, a Purified Lectin from Korean Mistletoe (Viscum album coloratum)
• 발행기관: 대한약학회
• 저자명: 강태봉(Tae Bong Kang) 윤택준(Taek Joon Yoon) 김종배(Jong Bae Kim) 송사유(Seong Kyu Song) 이관희(Kwan Hee Lee) 곽진환(Jin Hwan Kwak)
• 간행물 정보: 『약학회지』제45권 제3호 (2001년), 251~257쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.06.30

영문 초록

The study was carried out to evaluate the preliminary toxicity and general pharmacology of KML-IIU, a purified lectin com Korean Mistletoe (Visum album coloratum). KML-IIU was administered intravenously to ICR mice and Spargue-Dawley rats to investigate the acute toxicity. LD5O values in mice and rats were above 30mcg/kg. KML-IIU had no effects on the general behaviors, acetic acid induced writh- ing syndrome, pentobarbial induced sleeping time, pentylenetetrazole induced convulsion and the change of body temperature. In addition, KML-IIU did not show any effects on digestive system and blood coagulation system.

키워드

Korean Mistletoe Lectin KML-IIU LD50 General Pharmacology.