Computer Graphics: Quinolone계 항균제의 DNA-Interacalator에 관한 이론적 연구

• 영문명: Computer Graphics: Theoretical Study of Antibacterial Quinolone Derivatives as DNA-Intercalator
• 발행기관: 대한약학회
• 저자명: 서명은(Myung Eun Suh)
• 간행물 정보: 『약학회지』제39권 제1호 (1995년), 78~84쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.02.28

영문 초록

Based on Computer graphics molecular modeling method, quinolone derivatives as DNA-gyrase inhibitors formed stable DNA-intercalation complex with deoxycytidilyl-3'',5''-deoxyguanosine[d(CpG)2] dinucleotide. When d(CpG)2 and d(ApT)2 were compared in order to find out which DNA could form more stable DNA-Drug complex based on interaction energy and DNA-Drug complex energy, d(CpG)2 resulted in lower energy than d(ApT)2.