사상자 물추출물의 혈액 응고 작용

• 영문명: Hemostatic Action of Torilis fructus
• 발행기관: 대한약학회
• 저자명: 김환수(Hwan Su Kim) 박병욱(Pyeong Uk Park) 김기협(Key H. Kim) 박광식(Kwang Sik Park)
• 간행물 정보: 『약학회지』제39권 제1호 (1995년), 55~60쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.02.28

영문 초록

The acetone precipitates of the hot water extract of Torilis fructus showed strong hemostatic activity which was not inhibited by aspirin. This activity was not through platelet activation but possibly through activating some coagulation factors in plasma. The hemostatic action of the precipitates was not active by oral adminitration and no behavioral toxicity appeared in treated mice. However, mice treated with the acetone precipitates through tail vein showed serious tremor and then were killed probably by the thrombus produced in the body. The hemostatic activity was still remained after treatment with beta-glucosidase, beta-galactosidase, alpha-amylase, subtilisin BPN'', or trypsin but completely lost by acid hydrolysis. The active components seemed to be a complex of unidentified macromolecules to which some phenolic compounds were strongly bound.