이온 선택성 전극을 이용한 의약품 정량: Calix[4]arene과 Dibenzo-18-crown-6-ether에 의한 verapamil-선택성 polymeric membrane electrode

• 영문명: Ion-Selective Electrodes in Drugs Analysis: Verapamil-Selective Polymeric Membrane Electrodes Based on Calix[4]arene and Dibenzo-18-crown-6-ether Ionophores
• 발행기관: 대한약학회
• 저자명: 이은엽(Eun Yup Lee) 김성진(Sung Jin Kim) 김영학(Young Hak Kim) 김재현(Jae Hyun Kim) 허문회(Moon Hye Hur) 안문규(Moon Kyu Ahn)
• 간행물 정보: 『약학회지』제39권 제1호 (1995년), 61~67쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.02.28

영문 초록

PVC membrane electrodes based on the lipophilic neutral carrier, dibenzo-18-crown-6, cyclic oligomers of tert-butylphenol-formaldehyde condensates, calix[4]arenes as the active sensors for verapamil have been prepared and tested in a variety of plasticizers. At pH 5.0, the electrode exhibits a Nernstian response in the range of 1X10-2 ~ 5X10-5M verapamil with a slope of 49.1 +/- 0.5mV per concentration decade. The electrode constructed in this work can be used continuously for at least 1 month before any damage to the membrane occurs. And the analysis of the local anesthetic amine, which are good to select a specific compound in a mixed solution, were also accomplished by using of another neutral carrier, a DB18C6, for comparing with calix[4]arene.