Dithiocarbamate Chitosan을 Matrix로 이용한 고분자 약물의 개발: Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex의 생성 및 항균성

• 영문명: Development of Polymeric Drugs Utilizing Dithiocarbamate Chitosan: Formation and Antimicrobial Activities of Dithiocarbamate Chitosan-Ca(II)-Tetracycline Complex
• 발행기관: 대한약학회
• 저자명: 김윤택(Youn Taeg Kim) 김영미(Young Mi Kim) 한석규(Suk Kyu Han) 정연진(Yun Jin Jung) 유종호(Jong Ho Yu)
• 간행물 정보: 『약학회지』제39권 제1호 (1995년), 48~54쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1995.02.28

영문 초록

Coupling of tetracycline(Tc) to dithiocarbamate chitosan(DTCC) via chelate bond was investigated varying reaction time, concentration, temperature, pH, and Ca(II)/Tc ratio. The amount of Tc bound to matrix increased to give a maximum and decreased as the reaction proceeded. The degree and rate of dissociation of Tc complex were affected by the reaction temperature, and pH. By running the reaction at low temperature and pH, the degree of dissociation was greatly diminished. Properties of drug-release from DTCC-Ca(II)-Tc complex were studied by batch- and flow-method and release of Tc and Ca(II) by flow method followed nearly zero-order. DTCC-Ca(II)-Tc showed very prolonged antimicrobial activity compared to that of free Tc.