Phellinus linteus 균사 배양물로부터 분리한 단백다당체 Kp의 항암활성

• 영문명: Antitumor Activity of Kp, a Protein-polysaccharide from the Mycelial Culture of Phellinus linteus
• 발행기관: 대한약학회
• 저자명: 정경수(Kyeong Soo Chung) 김신숙(Shin Sook Kim) 김희수(Hee Soo Kim) 한만우(Man Woo Han) 김병각(Byoung Kak Kim)
• 간행물 정보: 『약학회지』제38권 제2호 (1994년), 158~165쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.04.30

영문 초록

A protein-polysaccaride fraction Kp(53.9% polysaccharide, 14.2% protein) was separated from the shake-cultured mycelia of a basidiomycetous fungus, Phellinus linteus, and its antitumor activity against sarcoma 180 in ICR mice was investigated. When administered after the tumor implantation, Kp exerted antitumor activity by inhibiting the growth of the sarcoma 180 solid tumor by 71.5% and increasing the life span of the sarcoma 180 ascitic mice by 51.5% at 100 mg/kg. In pretreatment tests, in which Kp was administered once daily for 9 days before the tumor implantation, Kp inhibited the growth of the solid and ascites form of sarcoma 180, respectively, by 35.4% and by 80.3% at 100 mg/kg. However, Kp showed no in vitro cytotoxic activity against a murine leukemia L1210 and a human gastric tumor SNU.1 upto the concentration of 200 mcg/ml. From these results, it is clear that the antitumor activity of Kp is exerted through its immunomodulating activity on the host''s immune system.

키워드

Phellinus linteus Kp basidiomycete shake-cultured mycelia protein-polysaccharide antitumor inimunomodulating sarcoma 180 leukemia L1210 SNU.1.