Ethanol이 Allyl alcohol 독성에 미치는 영향

• 영문명: Effect of Ethanol on Allyl alcohol-Induced Toxicity
• 발행기관: 대한약학회
• 저자명: 이주영(Joo Young Lee) 김대병(Dae Byung Kim) 문창규(Chang Kiu Moon) 정진호(Jin Ho Chung)
• 간행물 정보: 『약학회지』제38권 제2호 (1994년), 107~113쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.04.30

영문 초록

Ally alcohol is metabolized in the liver through two steps, first to reactive acrolein by alcohol dehydrogenase(ADH), subsequently to acrylic acid by aldehyde dehydrogenase(ALDH). Since ethanol could compete the same enzymes to be metabolized in the liver, we have studied the interaction between allyl alcohol and ethanol on liver toxicity. Simultaneous treatment of 2g/kg ethanol by ip administration with 40mg/kg allyl alcohol to rats increased the lethality significantly, accompanied by potentiation of the loss of hepatic glutathione. Collectively, these findings suggested that ethanol potentiated the hepatotoxicity and lethality induced by allyl alcohol probably through competing two metabolizing enzymes, ADH and ALDH.

키워드

Allyl alcohol acrolein ethanol acetaldehyde alcohol dehydrogenase(ADH) aldehyde dehydrogenase(ALDH).