흰쥐의 비강과 공장에서의 세픽심의 흡수기전

• 영문명: Absorption Mechanism of Cefixime through the Nasal Cavity and Jejunum in Rats
• 발행기관: 대한약학회
• 저자명: 박기배(Gee Bae Park) 노현구(Hyun Goo Roh) 이광표(Kwang Pyo Lee)
• 간행물 정보: 『약학회지』제38권 제2호 (1994년), 114~122쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.04.30

영문 초록

A study on the absorption mechanism of cefixime(CF), an oral alpha-amino group deficient cephalosporin antibiotic, has been undertaken through the rat jejunum and nasal cavity using an in situ simultaneous perfusion technique developed in our laboratory. CF was well absorbed in the jejunum and nasal cavity of rats at pH 5.0, but not at pH 7.0. CF absorption was studied over four orders of magnitude in concentration to determine saturability. Disappearance of CF in the perfusate followed first-order kinetics at all tested concentrations. The apparent first-order absorption rate constant was found to be dependent on the concentration over the range of 0.1mM-3mM in the jejunum and nasal cavity of rats. Inhibitors were added to determine the competitive inhibition of CF absorption. The presence of L-tyrosine, L-phenylalanine, alanine-alanine, glycine-glycine and cefadroxil produced the significant inhibition of CF absorption in the nasal cavity and jejunum. However, there was no evidence of the inhibition in the presence of cefazolin. In addition, The CF absorption in the nasal cavity and jejunum was inhibited significantly by ouabain and 2,4-dinitrophenol(DNP). This study suggested that CF is absorbed across the rat nasal cavity and jejunum by carrier-mediated transport mechanism and energy consuming system.

키워드

Cefixime nasal absorption jejunal absorption absorption mechanism carrier-mediated transport active transport.