랫트에 있어서 DWH-01(Ranitidine : Bismuth subcitrate : Sucralfate)의 아급성독성에 관한 연구

• 영문명: Subacute Toxicity of DWH-01(Ranitidine : Bismuth subcitrate : Sucralfate) in rats
• 발행기관: 대한약학회
• 저자명: 박선미(Sun Mee Park) 김형식(Hyung Sik Kim) 김용기(Yong Kee Kim) 변수현(Soo Hyun Byung) 연제덕(Je Deuk Yeon) 유영효(Young Hyo Yu) 이병무(Byung Mu Lee) 이향우(Hyang Woo Lee)
• 간행물 정보: 『약학회지』제37권 제4호 (1993년), 408~419쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.08.30

영문 초록

Subacute toxicities of DWH-01(Ranitidine : Bismuth : Sucralfate = 1.5 : 2 : 6) were inverstigated in Sprague-Dawley rats. After oral administration of DWH-01 with different dosages of 5g/kg, lg/kg, and 0.2g/kg, we examined the number of deaths, general signs, food intake, water intake, body weight and histopatholgical changes for both sexes of rats. During the adminstration period, urinalysis and opthalmological examination were also performed in the treated animals. 1) Animals were all survived for 4 weeks. 2) There were no significant differences in pathological and opthalmological findings between the control and treated animals. 3) There were no significant changes in body weight, food intake and water intake compared with control group. 4) In hematological examination and blood chemical analysis, there was no significant change compared with control group. 5) In histopathological examinations of organs and tissues, there was some hemorrhage in a lung tissue of low dose group, but it was thought to be caused by environmental factor. These data suggest that DWH-01 is not subacutely toxic in Sprague-Dawley rats.

키워드

Ranitidine sucralfate bismuth subacute toxicity.