토양에서 분리한 방선균의 항균력 및 암세포주 성장 억제능

• 영문명: Antimicrobial activity and tumor cell growth inhibition of an Actinomycete isolated from Korean soil
• 발행기관: 대한약학회
• 저자명: 한진호(Jin Ho Han) 김승철(Seung Cheol Kim) 장영수(Young Soo Chang) 염곤(Kon Ryeom)
• 간행물 정보: 『약학회지』제37권 제4호 (1993년), 389~396쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.08.30

영문 초록

An Actinomycetes strain JB isolated from Mt. Hanla had a strong antimicrobial activity against gram positive bacteria and tumor cell growth inhibition. Especially, it couldn''t degrade starch and casein as organic compounds. It was resist on lincomycin and rifampicin. The spore mass of strain JB which was arethrospore was white. DAP of the cell wall was L,L-DAP. Antimicrobial material was heat stable, dissolved in ethyl acetate, and not dissolved in butanol. In the pressnce of 0.1% phenol and 4% sodium chloride, strain JB could grow, but it didn''t growth at below 10oC . Strain JB didn''t use dextran, sodium acetate and sodium citrate as sole carbon source and L-cystein and L-thereonine as nitrogen source. The filtered broth of strain JB had the antimicrobial activity against gram positive bacteria, especially Staphylococcus aureus (ATCC 65389) and the growth inhibition of tumor cell line.

키워드

Actinomycete strain JB Staphylococcus aureus Tumor cell L.L-DAP.