카페인 약리작용에 민감한 지원자와 둔감한 지원자 및 뚱뚱한 쥐와 마른 쥐에 대한 카페인 약물동태 비교

• 영문명: Pharmacokinetics of Caffeine in Caffeine Sensitive and Non-Sensitive Volunteers, and in the Obese Rat and the Lean Rat
• 발행기관: 대한약학회
• 저자명: 윤정옥(Jeong Ok Yun) 권광일(Kwang Il Kwon)
• 간행물 정보: 『약학회지』제37권 제4호 (1993년), 341~349쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.08.30

영문 초록

To determine the reason of individual variation of the effect of caffeine, the absorption and the disposition of caffeine were studied in caffeine sensitive and caffeine nonsensitive volunteers. And also to study the effect of obesity on caffeine pharmacokinetics, the caffeine disposition in the obese rat and in the lean rat were investigated respectively. In result the caffeine sensitive group showed a longer terminal half-life of caffeine(7.35 +/- 0.71 hr : 5.49 +/- 0.73 hr) and a larger AUC (55.42 +/- 9.09mcg.ml-1.hr : 44.0 +/- 7.81 mcg.ml-1.hr) than that of caffeine non-sensitive group without statistical significance. The obese rat showed a longer terminal half-life (3.47 hr : 2.31 hr) and a larger AUC(35.3mcg.ml-1.hr : 26.97mcg.ml-1.hr) than that of the lean rat. But there was no correlation in the amount of daily caffeine consumption and obesity. In conclusion, we suggest that the individual variation of the effect of caffeine are being caused from the individual differences of caffeine susceptibility or tolerance rather than the differences of the genetic metabolic capacity or metabolic tolerance.

키워드

Caffeine coffee pharmacokinetics sensitive volunteer obese rat lean rat.