리팜피신에 내성인 Streptococcus faecalis 균주의 개발

• 영문명: Development of Streptococcus faecalis Strains Resistant to Rifampicin
• 발행기관: 대한약학회
• 저자명: 최응칠(Eung Chil Choi) 김승호(Seung Ho Kim) 권애란(Ae Ran Kwon) 이미정(Mi Jeong Lee) 오정자(Jeong Ja Oh) 김병각(Byong Kak Kim)
• 간행물 정보: 『약학회지』제37권 제4호 (1993년), 350~355쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.08.30

영문 초록

The preparation of Streptococcus faecalis RSI is used as a medicinal preparation for human intestinal disorders. But the microbe in this preparation is very sensitive to rifampicin. If this preparation is taken with rifampicin, its therapeutic effect can not be expected. To develope rifampicin resistant mutants, the rifampicin sensitive strain S. faecalis RSI was treated with N-methyl-N''-nitro-N-nitrosoguanidine(MNNG). Twelve strains of the MNNG-induced mutants showed distinct resistance to rifampicin and five mutants were selected for further studies. They also exhibited identical characteristics with the parent S. faecalis RSI when they were tested for lactic acid formation and growth inhibition of E. coli. From in vitro test, it was identified that rifampicin is not inactivated by certain factors of the rifampicin resistant mutants. Conclusively, the rifampicin resistant mutants are efficient strains that have insensitivity against rifampicin and original biochemical characteristics of the parent strain.

키워드

Streptococcus faecalis RSI N-methyl-N'-nitro-N-nitrosiguanidine(MNNG) rifampicin resistant mutant.