흰쥐 뇨에서의 Carbinoxamine의 대사체 확인

• 영문명: Indentification of Some Metabolites of Carbinoxamine in Rat Urine
• 발행기관: 대한약학회
• 저자명: 정병화(Byung Hwa Jung) 이선화(Seon Wha Lee) 김태욱(Tae Wook Kim) 정봉철(Bong Chul Chung) 박종세(Jong Sei Park)
• 간행물 정보: 『약학회지』제37권 제4호 (1993년), 317~324쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.08.30

영문 초록

The metabolic profile of carbinoxamine, 2-[(4-chlorophenyl)-2-pyridinyl-methoxy] N, N-dimethylethanamine, was determined in rat urine. Urinary extracts obtained with or without enzyme hydrolysis were derivatized with MSTFA/TMSCI (N-methyl-N-trimethylsilyl trifluoroacetamide/Trimethylchlorosilane) and analyzed by GC/MSD. In rat urine, which obtained after oral treatment with carbinoxamine maleate, chlorobenzolyl pyridine, (4-chlorophenyl)-2-pyridinyl methanol : carbinol, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N-methylethanamine : norcarbinoxamine, 2-[(4-chlorophenyl)2-pyridinylmethoxy]ethanamine : bis-norcarbinoxamine and parent carbinoxamine were detected in free form. Norcarbinoxamine and bisnorcarbinoxamine were also detected in conjugated form(acetylation). These data suggest that in the rat, hydroxylation of either the benzyl or pyridinyl ring can occur during carbinoxamine elimination. O-demethylation and subsequent conjugation represents the primary pathway of carbinoxamine elimination in the rat.

키워드

Carbinoxamine metabolism urine gas chromatography-mass spectrometry (GC-MS).