MR Molecular Imaging for Find Biological Processes of Occur in Breast Cancer

• 발행기관: 한국방사선학회
• 저자명: Hwunjae Lee Minju Park Jungmin Son Byungchea Lee Jisun Kim Guyrack Choi ByeoungJu Ahn Sangbock Lee
• 간행물 정보: 『한국방사선학회 학술대회 논문집』한국방사선학회 2014년 춘계종합학술대회논문집, 167~173쪽, 전체 6쪽
• 주제분류: 공학 > 기타공학
• 파일형태: PDF
• 발행일자: 2014.05.31

영문 초록

Novel diagnostic technique has been developed in many research area using targetable contrast agents with magnetic resonance imaging (MRI) for cancer diagnosis. It is efficient for cancer diagnosis to use MRI with biocompatible targeting moiety and magnetic nanoparticles (MNPs).Thus, we synthesized MNPs using thermal decomposition method which enable sensitive T2- or T2 Turbo spin echo (TSE) weighted magnetic resonance imaging. And it was coated with Hyaluronic acid (HA). Also we carried out that breast cancer cell line (MDA-MB-231) which has cancer stem cell property was injected in heterotopic mouse model. And then magnetic resonance sequence (T2) for imaging effects and targeting ability were analyzed into MNPs conjugated HA. We noted that MDA-MB-231cellwhich high-expressed CD44 ligand was showed contrast enhance efficiency through magnetic nanoparticles because of combining a lot of HA. As a result of these studies, we conclude that HA coated magnetic nanoparticles can be effectively used as a novel probe for visualizing of Breast cancer stem cell.

목차

Abstract

Ⅰ. Introduction

Ⅱ. EXPERIMENTAL METHOD

Ⅲ. RESULT AND DISCUSSION

Ⅳ. CONCLUSION

Reference