Cyclosporine A에 의한 급성뇌증 1례

• 영문명: A Case of Cyclosporine A-Induced Encephalopathy in a Child with Nephrotic Syndrome
• 발행기관: 대한소아신경학회
• 저자명: 배은주(Eun Joo Bae) 허준(Jun Huh) 이홍진(Hong Jin Lee) 박원일(Won Il Park) 이경자(Kyeung Ja Lee)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제8권 제2호, 342~346쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2000.12.20

국문 초록

저자들은 빈발 재발 신증후군으로 cyclosporine A 치료를 받던 환아에서 발병한 cyclosporine A에 의한 급성뇌증으로 의심되는 례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

영문 초록

Cyclosporine A is the most frequently used immunosuppressive agent for prevention of graft versus host disease(GVHD) and treatment of frequently relapsing nephrotic syndrome in childhood. Some adverse effects such as hepatic and renal toxicity, have been frequently encountered. But central nervous system toxicity caused by cyclosporine A is rare, and the incidence of encephalopathy among patients receiving cyclosporine A is unknown. Brain magnetic resonance imaging is an essential tool for diagnosis of cyclosporine A neurotoxicity. It typically demonstrates nonenhancing symmetric subcortical, and sometimes deep white matter changes resembling edema with posterior hemisphere predominance. We report a child with nephrotic syndrome who developed encephalopathy during cyclosporine A therapy. Based on this study, we emphasize that careful follow up of patient´s neurological finding is very important to prevent serious life-threatening complications.

키워드

Cyclosporine A Encephalopathy