Warfarin, Dansylsarcosine의 알부민결합에 미치는 유리지방산의 영향

• 영문명: Influences of Free Fatty Acid on the Albumin Binding of Warfarin and Dansylsarcosine
• 발행기관: 대한약리학회
• 저자명: 배진우(Jin-Woo Bae)
• 간행물 정보: 『대한약리학잡지』제30권 제2호, 255~262쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

There are some reports about the influences of free fatty acids on the albumin binding of drugs. But they were concerned to the limited free fatty acids, mostly of azapropazone-warfarin bidning site bound drugs and determination of dissociation and association constants by stopped flow technique. These data were not enough to make conculsions for the general tendency of free fatty acid to albumin binding. Therefore the influence of various saturated fatty acids of C_{10 ~ 20}, oleic acid and linoleic acid as unsaturated fatty acids to albumin binding of warfarin and dansylsarcosine were studied by equilibrium dialysis. The concentration of free drug was determined by spectrophotometer according to the molar ratios of 0, 0.5, 1, 2 and 4 between free fatty acid and albumin. There were significant increasing in the free durg concentration of warfarin and dansylsarcosine when the molar ratio for capric acid, lauric acid and palmitic acid was 4. The free warfarin concentration was increased significantly at a molar ratio of 4 between oleic acid and albumin. Therefore the albumin binding of durgs can be variated significantly by increased free fatty acid of diabetics and cause to the pharmacokinetic variation between healthy and diabetics.

키워드

Albumin binding Free fatty acids Warfarin Dansylsarcosine Equilibrium dialysis