Biphenyldimethyl dicarboxylate(DDB)가 Ethanol 유발 간독성 흰쥐에서의 지질 과산화와 Oxygen Free Radical 제거 효소 활성도 및 간기능에 미치는 영향

• 영문명: Effects of Biphenyldimethyl dicarboxylate(DDB) on the Lipid Peroxidation, Oxygen Free Radical Scavenging Enzymes Activities and Hepatic Functions in Ethanol-induced Hepatotoxic Rats
• 발행기관: 대한약리학회
• 저자명: 송호연(Ho-Yeon Song) 하경란(Kyung-Ran Ha) 고현철(Hyun-Chul Koh) 신인철(In-Chul Shin) 서대규(Tae-Kyu Suh)
• 간행물 정보: 『대한약리학잡지』제30권 제2호, 217~226쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

In an attempt to define the effects of Biphenyldimethyl dicarboxylate(DDB) on the lipid peroxidation, oxygen free radical scavenging enzymes activities and hepatic functions in ethanol-induced hepatotoxic rats, we studies malondialdehyde(MDA) level and the activities of catalse, superoxide dismutase(SOD), glutamic-oxaloacetic transaminase(GOT) and glutamic-pyruvic transaminase(GPT) in liver of the rats at 24, 48 and 72 hr after the injection of ethanol and DDB. Sprague-Dalwey albino rats weighing 250 to 280gm were injected intraperitoneally with ethanol(2.5 gm/kg ) only and ethanol plus DDB(300mg/kg ). The result obtained can be summarized as follows : 1) The group treated with ethanol showed significantly higher MDA level and lower catalase and SOD activities at 24, 48 and 72hr after the injection as compared with that of control group. 2) The group treated with ethanol showed significantly higher GOT and GPT activities at 24, 48 and 72hr after the injection as compared with that of control group. 3) The group treated with ethanol plus DDB showed significantly lower MDA level and higher catalase and SOD activities at 24, 48 and 72 hr after the injection as compared with that of ethanol group. 4) The group treated with ethanol plus DDB showed significantly lower GOT and GPT activities at 24, 48 and 72 hr after the injection as compared with that of ethanol group. These results suggest that the excessive oxygen free radicals resulting from the depression of the activities of catalase and superoxide dismutase is an important determinant in pathogenesis of ethanol-induced hepatotoxicity and DDB has antioxidant effects.

키워드

Biphenyldimethyl dicarboxylate(DDB) Ethanol Catalase Malondialdehyde(MDA) Superoxide dismutase(SOD)