새로운 Anthracycline계 항암제 DA-125의 일반약리작용

• 영문명: General Pharmacology of DA-125, A New Anthracycline Anticancer Agent
• 발행기관: 대한약리학회
• 저자명: 김명석(Myung-Suk Kim) 박종완(Jong Wan Park) 김영훈(Young Hoon Kim) 김순회(Soon Hoe Kim) 신명수(Myeong Soo Shin) 김원배
• 간행물 정보: 『대한약리학잡지』제30권 제2호, 227~242쪽, 전체 16쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

The general pharmacological effects of a new anthracycline anticancer agent, DA-125 [7-0-(2, 6-dideoxy-2-fluoro-α-L-talopyranosyl)-adriamycinone-14-β-alaninate⋅HCI] were investigated in mice, rats, guinea pigs, rabbits and dogs. Intravenous administration of DA-125 presented no significant effects on the central and peripheral nervous systems of ICR mice except a decrease in the numbers of acetic acid-induced writhing response at a dose of 10 mg/kg. In anesthetized rats and dogs, DA-125 produced a transient depression of blood pressure and an increase in heart rate, but did not affect the peripheral blood flow in the isolated ear vessels of rabbits and the mechanical functions of the isolated hearts of guinea pigs. No significant effects were observed on the gastrointestinal functions and the contractilities of smooth muscle preparations obtained from guinea pig trachea, rabbit ileum, pregnant and non-pregnant uterus and vas deferens of rats. DA-125 Increased the contractility of the isolated ileum of guinea pigs in a dose range of 10^-6 ~ 10^-9g/ml, and also increased, but weaker than adriamycin, the vascular permeability in rat skin. DA-125 had no effect on the kallikrein-induced increase in permeability and the permeability of the visceral organs. DA-125 did not adversely affect the liver function and the blood coagulation system, and did not induce hemolysis in vitro. It is concluded from the results that the general pharmachological effects of DA-125 are similar to or weaker than those of adriamycin, and that little adverse effects are anticipated with a therapeutic dose range.

키워드

DA-125 New anthracycline anticancer agent General pharmacology