흰쥐 심방근에서의 Purinergic 수용체의 특성

• 영문명: Characterization of Purinergic Receptors in Rat Atrium
• 발행기관: 대한약리학회
• 저자명: 김재하(Jae Ha Kim)
• 간행물 정보: 『대한약리학잡지』제30권 제2호, 181~190쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

In rat atrium the characteristics of purinergic receptors were investigated by observing the effects of some purinergic receptor agonists and antagonists on action potential and contractile force. The statistically significant effects of ATP(10^-6 ~ 10^-3M) and adenosine (10^-6 ~ 10^-3M) on normal action potential characteristics were a dose-dependent shortening of action potential duration (APD₉₀) by both agents and hyperpolarization by ATP(10^-4,10^-3M). CAP(10^-8 ~ 10^-4M), an A₁ adenosine receptor agonist, shortened (APD₉₀) markedly in a dose-dependent manner and these effects were almost abolished by DPCPX (10^-6 M), an A₁, adenosine receptor antagonist, but not affected by DMPX(2 X 10^-6 M), an A₂ adenosine receptor agonist. On the other hand, CGS 21680(10^-7 ~ 10^-4M), an A₂ adenosine receptor agonist, elicited a slight shortening of (APD₉₀) and these effects were inhibited by DPCPX but persisted in the presence of DPMX. Adenosine (10^-6 ~ 10^-4 M) decreased the basal contraction of atrial muscle in a dose-dependent manner and these effects were not inhibited by DMPX but by DPCPX. These results suggests that purinergic receptor agonists depress the cardiac activity by a short ening of action potential duration and this effect is mostly mediated by A₁ adenosine receptors in rat atrium.

키워드

Purinergic receptor Action potential Contractile force