정상 20대 남자에서 Zopiclone이 수면에 미치는 영향 - 수면다원검사 결과를 중심으로 ᅳ

• 영문명: The Effects of Zopiclone on Sleep of Normal Adult Males in Their Twenties — Focused on Polysomnographic Findings —
• 발행기관: 대한신경정신의학회
• 저자명: 이상규 김인 서광윤
• 간행물 정보: 『신경정신의학』제34권 제1호, 299~308쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.01.30

영문 초록

Objects * As classic hypnotics had been reported to have adverse effects of cognitive problems, daytime drowsiness, addiction and others, non-benzodiazepine hypnotics received much clinical attention recently and zopiclone, a cyclopyrrolone derivative, has been introduced as a new hypnotic. The purpose of this study is to evaluate the effects of zopiclone on sleep by polysomnography. Methods : The subjects were 13 normal adult males in their twenties. They received placebo and zopiclone 7.5mg alternatively in a double blind cross over design and on each night, their sleep were recorded by polysomnography. Assessments by using subjective symptoms questionnaire were performed to check the residual effects o f zopiclone on the following day. Results: 1) There was no significant difference o f total sleep time between placebo and zopiclone nights. . 2) Sleep efficiency was increased after the administration of zopiclone(p〈0.05). 3) Sleep latency was not decreased after the administration of zopiclone. 4) Zopiclone increased deep sleep, i.e., the sum o f stage 3 and 4 sleep (p<0.01). 5) Zopiclone did not change R EM sleep significantly. 6) Zopiclone reduced wake time and frequency during sleep(p<0.01). 7) Zopiclone did not cause daytime drowsiness but produced bitter taste more than placebo (p<0.01). Conclusion : Zopiclone is found to have effects of maintaining sleep and increasing deep sleep and sleep efficiency, but has no significant sleep-inducing effects. R EM sleep does not seem to be affected significantly by zopiclone. Some o f the subjects reported bitter taste after the administration o f zopiclone.

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연구대상 및 방법

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Zopiclone Polysomnography Sleep