腦影像術을 通한 腦의 形態學的 分析 方法論 硏究

• 영문명: Methods for the Quantitative Morphologic Analysis of Cross-Sectional B rain Images
• 발행기관: 대한신경정신의학회
• 저자명: 김주한 이정희 우종인
• 간행물 정보: 『신경정신의학』제34권 제4호, 1204~1215쪽, 전체 12쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.07.30

영문 초록

Objects : For the quantification and topographic analysis of cross-sectional brain images, Methods : The authors developed a planimetric method with boundary tracing, image digitizing and pixel counting. And each axial brain image was splitted into unit sectors of equal area, using polar coordinates as the frame of reference with its origin at the center of the symmetry line of the brain image. The sectors were reconstructed on a radial coordinates so as to represent the topographic profiles o f the C SF spaces. A M R I study with these methods was performed in 26 Alzheimer patients(age, 722土 7.0) according to N IN C D S-A D R D A criteria and 22 normal control subjects(age, 71.5±5.4). Results : Alzheimer patients showed greater ventricular and cerebral (cortical and ventricular) atrophy than control subjects(p〈0.05). In healthy volunteers, all the cerebral atrophy indices measured exhibited significant correlation with ageCp^O.OOS), but not in Alzheimer patients. Analysis of the topographic profiles o f the Alzheimer and control groups demonstrated that the lateral ventricles of the Alzhiemer group showed more dilatation in all directions and showed accentuated dilatation in frontal and Conclusion : These methods could be useful changes in cross-sectional brain images. occipital horns. in quantifying and characterizing morphologic

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키워드

Methodology Brain atrophy Dementia of the alzheimer type Topographic analysisM R I