정신분열증 환자의 H aloperidol과 Fluoxetine의 상호작용에 관한 연구

• 영문명: A Study of Interaction Between Haloperidol and Fluoxetine in Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 신민철 정한용 한선호
• 간행물 정보: 『신경정신의학』제34권 제4호, 1194~1203쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.07.30

영문 초록

Objects : The aim of this study was to determine the pharmacokinetic interaction between fluoxetine and haloperidol after fluoxetine trial in haloperidol-stabilized schizophrenics. Methods : Fluoxetine was added for 6 weeks to stable doses of haloperidol given to 32 schizophrenic inpatients. Then, using a HPLC equipped with UV detector, the authors measured plasma concentrations of haloperidol, reduced haloperidol and total haloperidol. Results : 1) After fluoxetine was added, mean plasma haloperidol concentrations were increased significantly at 2nd week(p<0.05) and were decreased significantly at 6th week(p<0.05). 2) Mean plasma reduced haloperidol concentrations were increased significantly at 2nd week (p

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키워드

Fluoxetine Haloperidol Reduced haloperidol Schizophrenia

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