정신분열증 유형 및 경과 변화에 따른 혈청면역글로부린 변화

• 영문명: The Change of Serum Immunoglobulin Level in Type and Course of Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 손인기 이재광 박두병
• 간행물 정보: 『신경정신의학』제34권 제4호, 998~1006쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.07.30

영문 초록

Objects : In this study the authors tried to elucidate any relationship between schizophrenia and the im mune function by measuring the serum im munoglobulin level in schizophrenic patients and observing the changes of the serum im munoglobulin in the clinical course and type. Methods • The subjects of this study were 28 schizophrenics who had been admitted to the Neuropsychiatric Department of Chung Ang University Hospital and a private neuropsychiatry clinic and 20 healthy young /adults were recruited for control. On admission and after one month later, the serum im m unoglobulin concentration and PANSS were serially evaluated. The collected data were analysed through the SPSS program. Applied statistic methods were Mann-Whitney U test, Kruskal-Wallis test and Pearson’s correlation. Results : 1) Only Ig A concentration of schizophrenic patients was significantly higher than that of normal controls. 2) There was no significant difference between positive and negative schizophrenic patients, but both positive and negative schizophrenic patients showed a significantly higher concentration of Ig A than controls. 3) Age was positively correlated with Ig A concentration in schizophrenic patients. 4) Each Ig concentration of schizophrenics tended to decline on the clinical course, but it was not statistically significant 5) In schizophrenic patients, each Ig concentration at admission was not related to degree of improvement of psychotic symptoms and dosage of antipsychotic medication had no in fluence on each Ig concentration. Conslusion In summary, it was postulated that immune system abnormality contributed to pathology of schizophrenia. But im mune system abnormalities might be due to altered stress response in schizophrenia. Therefore further research for relationship of stress-schizophreniaim mune system is needed to support these interpretations. Also between positive and negative schizophrenia, im mune function or stress response showed no difference

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대상 및 방법

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참고문헌

키워드

Schizophenia symptom Positive symptom Negative symptom Immunoglobulin