抗精神病藥物에 依한 無顆粒細胞症 治驗 1例

• 영문명: A Case of Neuroleptic-Induced Agranulocytosis
• 발행기관: 대한신경정신의학회
• 저자명: 吳東財 申榮宇 張焕 ᅳ 趙京杉 朴康圭
• 간행물 정보: 『신경정신의학』제24권 제1호, 156~161쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1985.02.28

영문 초록

The authors experienced a female schizophrenic patient who revealed severely decreased leucocytes (350/mm3) w ith the manifestation of h ig h fever, chillness and sore throat after the oral administration of neuroleptics. Agranulocytosis induced with the use of neuroleptic drugs has been well known complication in psychiatric practice although it is quite rare. In this case, following the combined use of neuroleptics (thioridazine halopondol and chlorproonazine), severe decrement of leucocytes (mainly lymphocytes with few neutrophils) was noticed on peripheral blood and marked decrement of erythroid series, especially of myeloid series, with decrement of total cellular elements were confirmed through the biopsy of bone marrow. She did not responded at all to the massiveadministration of antibiotics, but dramatic improvement was noticed both clinically and in the follow-up biopsy findings of bone marrow after two times trial of leukapheresis

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