AFP 검사방법 단축에 관한 고찰

• 영문명: Simplification of One Step Immunotech AFP Test
• 발행기관: 대한핵의학기술학회
• 저자명: 문기춘(Ki Choon Moon) 권원현(Won Hyun Kwon) 김정인(Jung In Kim) 이인원(In Won Lee)
• 간행물 정보: 『핵의학기술』Vol.17 No.1, 80~84쪽, 전체 5쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

Purpose: The Immunotech AFP is a widely used test in 14 hospitals(RIA QC establishments: 46) as a liver tumor marker. Normally, the test takes 45 minutes including complicated 2 step method. We evaluated the possibility of 1 step method and suitable test time. Materials and Methods: Samples of 31 patients in SNUBH were used as subject. We evaluated the sensitivity, intra and inter assay precision, recovery rate, linearity between 1 step and 2 step method (45 min. and 60 min.). Results: Both of 45 minutes and 60 minutes test showed 0.1 ng/mL sensitivity. In 45 minutes test, the intra assay coefficients of variation were 3.05%, 3.43%, 1.68%. Also, inter assay coefficients of variation were 3.91%, 2.38%, 0.82%. In 60 minutes test, the intra assay were 5.00%, 3.69%, 1.97%, inter assay were 3.14%, 3.71%, 1.85%.The correlation coefficient of each 2 step and 1 step (45 min.), 2 step and 1 step(60 min.), 1 step (45 min.) and 1 step (60 min.) were y=0.9293x+2.7356 (R²=0.9999), y=0.9193x+4.1002 (R²=0.9993), y=0.9894x+1.3805 (R²=0.9997). Conclusion: Compared 1step method to 2 step method, both method showed very reasonable precision, recovery rate and correlation coefficient. Also, 1 step method(45 min.) of correlation coefficient (R²) was 0.999. We suggest that 1 step method test can reduce the test time and is useful for AFP test.

목차

서론

대상 및 방법

결과

결론 및 고찰

요약

참고문헌

키워드

Precision Recovery rate Correlation coefficient