Oldenlandia diffusa Ameliorates on Atopic Dermatitis in Mice

• 영문명: Oldenlandia diffusa Ameliorates on Atopic Dermatitis in Mice
• 발행기관: 한국자원식물학회
• 저자명: 양미옥(Mi-Ok Yang) 명노일(Noh-Yil Myung)
• 간행물 정보: 『한국자원식물학회지』제36권 제6호, 556~561쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Oldenlandia diffusa (OD), a member of the Rubiaceae family, has been used for treating inflammatory and infectious diseases. However, the anti-atopic effects of OD are not completely understood yet. Thus, the aim of the present study was to elucidate beneficial effects of OD on atopic dermatitis (AD) in vivo. We examined the pharmacological effects of OD on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced AD-like skin lesions in mice. Additionally, we evaluated regulatory effects of OD on the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in DNCB-induced AD-like skin lesions. Results showed that OD inhibited the scratching behavior and AD symptoms. It also decreased serum levels of IgE and histamine in mice. Moreover, OD significantly ameliorated the expression of IL-6 and TNF-α in AD-like skin lesion. These finding suggest experimental evidence of that OD’s potential for treating AD.

목차

Introduction

Materials and Methods

Results

Discussion

Acknowledgments

Conflicts of Interest

References

키워드

Atopic dermatitis Inflammatory cytokine Oldenlandia diffusa