Hibiscus manihot leaves Attenuate Accumulation of Lipid Droplets by Activating Lipolysis, Browning and Autophagy, and Inhibiting Proliferation of 3T3-L1 Cells

• 영문명: Hibiscus manihot leaves Attenuate Accumulation of Lipid Droplets by Activating Lipolysis, Browning and Autophagy, and Inhibiting Proliferation of 3T3-L1 Cells
• 발행기관: 한국자원식물학회
• 저자명: 금나경(Na Gyeong Geum) 최정원(Jeong Won Choi) 최혁진(Hyeok Jin Choi) 류광현(Gwang Hyeon Ryu) 정진부(Jin Boo Jeong)
• 간행물 정보: 『한국자원식물학회지』제36권 제6호, 541~548쪽, 전체 8쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

In the present study, the effects of HML on lipolysis, adipocyte browning, autophagy, and proliferation were investigated. HML affected lipolysis by increasing the protein levels of ATGL and HSL, and phosphorylation levels of HSL and AMPK. Furthermore, HSL decreased the perilipin-1 levels. In addition, free glycerol content was increased by HML treatment. HML affected adipocyte browning by increasing the protein levels of UCP-1, PGC-1α, and PRDM16. In addition, HML affected autophagy by increasing the levels of LC3-I and LC3-II, and decreasing those of SQSTM1/p62. Moreover, HML affected adipocyte proliferation by suppressing the proliferation of 3T3-L1 cells due to arrest of the cell cycle via blocking the expression of β-catenin and cyclin D1. These results suggest that HML induces lipolysis, adipocyte browning, autophagy, and inhibits excessive proliferation of adipocytes.

목차

Introduction

Materials and Methods

Results and Discussion

Acknowledgments

Conflicts of Interest

References

키워드

Anti-obesity activity Hibiscus manihot Adipocytes Lipolysis Adipocyte browning Autophagy Adipocyte proliferation