Hijikia fusiforme Attenuate the Mast Cell-mediated Inflammatory Response through NF-kB Pathway Regulation

• 영문명: Hijikia fusiforme Attenuate the Mast Cell-mediated Inflammatory Response through NF-kB Pathway Regulation
• 발행기관: 한국자원식물학회
• 저자명: 김수진(Su-Jin Kim)
• 간행물 정보: 『한국자원식물학회지』제36권 제6호, 549~555쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Hijikia fusiforme (HF), a member of brown algae family, exerts various pharmacological effects, including preventing arteriosclerosis and menopausal disorders. This study aimed to elucidate the ameliorative effect of HF on skin inflammation. We investigated the antioxidant and anti-inflammatory effect of HF extract to evaluate its potential as a functional materials. The antioxidant activity of HF was determined using 2,2-diphenyl-1-picrylhydrazy (DPPH) scavenging and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) scavenging. To determine the pharmacological mechanism of HF in inflammatory reaction, we evaluated the effects of HF on interleukin (IL)-8, IL-6 and tumor necrosis factor (TNF)-α production and nuclear factor-κB (NF-κB) activation in activated- human mast cells (HMC)-1. Results showed that HF had the high DPPH and ABTS+ radical scavenging activity, and it suppressed IL-8, IL-6 and TNF-α production in a concentration-dependent manner. Moreover, HF significantly ameliorated NF-kB activation in activated-HMC-1. Hence, these results provide evidence that HF’s potential for skin inflammation therapy

목차

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Conflicts of Interest

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키워드

Hijikia fusiforme Mast cells Nuclear factor-κB Skin Inflammation