전층각막이식 환자에서 발병한 Paecilomyces lilacinus 진균 각막염 1예

• 영문명: A Case of Fungal Keratitis Caused by Paecilomyces lilacinus after Penetrating Keratoplasty
• 발행기관: 대한안과학회
• 저자명: 원재연 신지영 황제형 주천기,Jae Yon Won, MD, Ji Young Shin, MD, Je Hyung Hwang, MD, Choun-Ki Joo, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number9, 1384~1387쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.09.15

영문 초록

Purpose: To report a case of corneal ulcer caused by Paecilomyces lilacinus after penetrating keratoplasty. Case summary: A 67-year-old male with a history of penetrating keratoplasty in the left eye 7 years prior and re-penetrating keratoplasty in the left eye due to graft failure in June 2013, visited our clinic for ocular pain and conjunctival injection in the left eye 3 days in duration. Corneal scrapings were performed for Gram and fungal stains and cultures. The patient was admitted to the hospital for hourly topical fortified ceftazidime and amphotericin B. Despite intensive topical therapy, no improvement was observed. Three days later, fungal culture confirmed Paecilomyces lilacinus and topical voriconazole was prepared from the intravenous formulation and was administered topically and intravenously. Despite medical therapy with voriconazole, perforation occurred requiring a tectonic keratoplasty. Conclusions: Keratitis caused by Paecilomyces lilacinus is difficult to eradicate and refractory to amphotericin B. We suggest early use of topical eyedrops, intracameral, and intravitreal injections of voriconazole may be an appropriate treatment for patients with Paecilomyces lilacinus keratitis. J Korean Ophthalmol Soc 2014;55(9):1384-1387

키워드

Corneal ulcer, Paecilomyces lilacinus, Penetrating keratoplasty